CD178


ArtNr	20-783-74242
Hersteller	GENWAY
Menge	100 TESTS
Kategorie	Oncology Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	FC
Clon	14C2
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-E63B2D
Similar products	20-783-74242
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Genway ID:	GWB-E63B2D
Specificity:	CD178NCBI
Gene ID:	356
Specificity:	CD178
Clone:	14C2
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the P3U1 myeloma cell line.
Specificity Note:	This product recognises the human CD178 cell surface antigen a 40kDa glycoprotein also known as Fas ligand (CD95L). CD178 is a member of the TNF family which is expressed by activated T lymphocytes and NK cells. The protein may exist as either a membrane bound or a cleaved soluble form. CD178 plays an important role in T cell development cytotoxicity. Binding of CD178 to Fas (CD95) results in the induction of apoptosis. Clone 14C2 is not reported to have a blocking function. We recommend the use of for functional studies.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute with 1 ml distilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat
Function:	Cytokine that binds to TNFRSF6/FAS a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Subunit:	Homotrimer (Probable).
Subcellular Location:	Cell membrane; Single-pass type II membrane protein. Secreted. Note=May be released into the extracellular fluid probably by cleavage form the cell surface.
Ptm:	N-glycosylated.
Ptm:	The soluble form derives from the membrane form by proteolytic processing.
Disease:	Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
Similarity:	Belongs to the tumor necrosis factor family. 1. Legembre. P. et al. (2005) Amplification of Fas-Mediated Apoptosis in Type II Cells via Microdomain Recruitment.

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