CD178


Item no.	20-783-74242
Manufacturer	GENWAY
Amount	100 TESTS
Category	Oncology Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Applications	FC
Clone	14C2
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-E63B2D
Similar products	20-783-74242
Available
Genway ID:	GWB-E63B2D
Specificity:	CD178NCBI
Gene ID:	356
Specificity:	CD178
Clone:	14C2
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the P3U1 myeloma cell line.
Specificity Note:	This product recognises the human CD178 cell surface antigen a 40kDa glycoprotein also known as Fas ligand (CD95L). CD178 is a member of the TNF family which is expressed by activated T lymphocytes and NK cells. The protein may exist as either a membrane bound or a cleaved soluble form. CD178 plays an important role in T cell development cytotoxicity. Binding of CD178 to Fas (CD95) results in the induction of apoptosis. Clone 14C2 is not reported to have a blocking function. We recommend the use of for functional studies.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute with 1 ml distilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat
Function:	Cytokine that binds to TNFRSF6/FAS a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Subunit:	Homotrimer (Probable).
Subcellular Location:	Cell membrane; Single-pass type II membrane protein. Secreted. Note=May be released into the extracellular fluid probably by cleavage form the cell surface.
Ptm:	N-glycosylated.
Ptm:	The soluble form derives from the membrane form by proteolytic processing.
Disease:	Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
Similarity:	Belongs to the tumor necrosis factor family. 1. Legembre. P. et al. (2005) Amplification of Fas-Mediated Apoptosis in Type II Cells via Microdomain Recruitment.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 TESTS

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Delivery expected until 8/28/2025

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