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Met (Phospho-Tyr1349) Antibody Blocking Peptide

Met (Phospho-Tyr1349) Antibody Blocking Peptide

ArtNr	06-785-213182
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Peptides & Proteins Peptides By Organ Gastric Cancer
Typ	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-F12AB5
Similar products	06-785-213182
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Genway ID:	GWB-F12AB5
Function:	Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
Catalytic Activity:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:	Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1 SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356 interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10 as well as SPSB1 SPSB2 SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF however HGF treatment has a positive effect on this interaction.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Domain:	The kinase domain is involved in SPSB1 binding.
Disease:	Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.
Disease:	Defects in MET may be associated with gastric cancer.
Disease:	Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].
Disease:	Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.
Disease:	Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication a lack of reciprocal social interaction or responsiveness and restricted stereotypical and ritualized patterns of interests and behavior.
Similarity:	Belongs to the protein kinase superfamily. Tyr protein kinase family.
Similarity:	Contains 3 IPT/TIG domains.
Similarity:	Contains 1 protein kinase domain.
Similarity:	Contains 1 Sema domain.

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Menge: 0.1 mg

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Lieferung vsl. bis 28.08.2025

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