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Met (Phospho-Tyr1349) Antibody Blocking Peptide

Met (Phospho-Tyr1349) Antibody Blocking Peptide

Item no.	06-785-213182
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Peptides & Proteins Peptides By Organ Gastric Cancer
Type	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-F12AB5
Similar products	06-785-213182
Available
Genway ID:	GWB-F12AB5
Function:	Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
Catalytic Activity:	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit:	Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1 SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356 interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10 as well as SPSB1 SPSB2 SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF however HGF treatment has a positive effect on this interaction.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Domain:	The kinase domain is involved in SPSB1 binding.
Disease:	Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.
Disease:	Defects in MET may be associated with gastric cancer.
Disease:	Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].
Disease:	Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.
Disease:	Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication a lack of reciprocal social interaction or responsiveness and restricted stereotypical and ritualized patterns of interests and behavior.
Similarity:	Belongs to the protein kinase superfamily. Tyr protein kinase family.
Similarity:	Contains 3 IPT/TIG domains.
Similarity:	Contains 1 protein kinase domain.
Similarity:	Contains 1 Sema domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 8/28/2025

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