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TRIB2 Antibody (N-term)

TRIB2 Antibody (N-term)

ArtNr	ABC-AP8930a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)
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Primary Accession	Q92519
Antigen Type	Synthetic Peptide
Application	FC, IHC-P, WB
Bio Background	TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Bio References	Hegele, R.A., et.al., Hum. Mol. Genet. 18 (21), 4189-4194 (2009) Eder, K., et.al., Int. Immunol. 20 (12), 1543-1550 (2008)
Clonality	Polyclonal
Clone/Animal Names	RB9215
Gene ID	28951
Gene Name	TRIB2 (HGNC:30809)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of TRIB2 (arrow) using rabbit polyclonal TRIB2 N-term (Cat. #AP8930a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TRIB2 gene (Lane 2) .
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	TRIB2 Antibody (N-term) (Cat. #AP8930a) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TRIB2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	TRIB2 Antibody (N-term) (Cat. #AP8930a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Other Accession	Q8K4K3; Q5GLH2; NP_067675
Predicted	B, M
Isotype	Rabbit Ig
Calculated MW	38801
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This TRIB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRIB2.
NCBI Accession	NP_067675.1

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