7-Methylguanine

ArtNr	HY-113352-100mg
Hersteller	MedChem Express
CAS-Nr.	578-76-7
Menge	100 mg
Quantity options	100 mg 50 mg 5 mg
Kategorie	Reagents & Chemicals Biochemicals
Typ	Chemicals
Specific against	other
Purity	99.97
Citations	[1]Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1.\|[2]Kurgina TA, et al. Inhibitory Effects of 7-Methylguanine and Its Metabolite 8-Hydroxy-7-Methylguanine on Human Poly(ADP-Ribose) Polymerase 1. Biochemistry (Mosc). 2022 Aug;87(8):823-831.\|[3]Nilov D, et al. Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine. Int J Mol Sci. 2020 Mar 20;21(6):2159. \|[4]Kirsanov K, et al. Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity. Front Pharmacol. 2022 Jul 6;13:842316. \|[5]Gaubatz JW, et al. Introduction, distribution, and removal of 7-methylguanine in different liver chromatin fractions of young and old mice. Mutat Res. 1997 Apr 14;375(1):25-35. \|[6]Kirsanov K, et al. 7-Methylguanine Inhibits Colon Cancer Growth in Vivo. Acta Naturae. 2024 Apr-Jun;16(2):50-52.
Smiles	O=C1NC(N)=NC2=C1N(C)C=N2
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Endogenous Metabolite; PARP
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	165.15
Product Description	7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions[1][2][3][4][5][6].
Manufacturer - Research Area	Cancer
Solubility	1M NaOH: 100 mg/mL (ultrasonic)\|H2O: 4.72 mg/mL (ultrasonic; adjust pH to 11 with 1 M NaOH)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite; PARP1
Clinical information	No Development Reported

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HY-113352-100mg-safety-datasheet.pdf