Protectin D1

ArtNr	HY-130413-10ug
Hersteller	MedChem Express
CAS-Nr.	660430-03-5
Menge	10 ug (138.7 uM x 200 uL in ethanol)
Quantity options	10 ug (138.7 uM x 200 uL in ethanol) 50 ug (138.7 uM x 1 mL in ethanol)
Kategorie	Reagents & Chemicals Biochemicals
Typ	Chemicals
Specific against	other
Purity	99.10
Citations	[1]Tungen JE, et al. Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018;16(36):6818-6823.\|[2]Serhan CN, et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [published correction appears in J Immunol. 2006 Mar 15;176(6):3843]. J Immunol. 2006;176(3):1848-1859.\|[3]Zhang P, et al. Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway. J Cardiovasc Transl Res. 2024 Apr;17(2):376-387.
Smiles	CC/C=C\C[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\C/C=C\CCC(O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Neuroprotectin D1,NPD1
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Akt; Caspase; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; MicroRNA; PI3K; Reactive Oxygen Species (ROS)
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Molecular Weight	360.49
Product Description	Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders[1][2].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Isoform	Human Endogenous Metabolite; IL-1
Clinical information	No Development Reported

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HY-130413-10ug-safety-datasheet.pdf