Thioridazine

ArtNr	HY-B0965A-5mg
Hersteller	MedChem Express
CAS-Nr.	50-52-2
Menge	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 200 mg 25 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Molecules
Specific against	other
Purity	99.50
Citations	[1]Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31(3):519-22.\|[2]Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31(5):2107-14.\|[3]Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17(9):989-97.\|[4]Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel). 2021 Apr 23;13(9):2045. Int J Mol Sci. 2023, 24(2), 1635.\|Br J Cancer. 2024 Aug 22.\|Int J Biol Macromol. 25 December 2021.\|Pol J Microbiol. 2019 Dec;68(4):477-491.
Smiles	CSC(C=C1N2CCC3N(C)CCCC3)=CC=C1SC4=C2C=CC=C4
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	5-HT Receptor; Apoptosis; Autophagy; Bacterial; Dopamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	370.57
Product Description	Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Clinical information	Launched

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Menge: 5 mg

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