NB-598

ArtNr	HY-16343-25mg
Hersteller	MedChem Express
CAS-Nr.	131060-14-5
Menge	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Kategorie	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	98.69
Citations	[1]Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45.\|[2]Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305.\|[3]Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51. Adv Sci (Weinh). 2023 Sep;10(27):e2206878.\|Antioxidants (Basel). 2024 Jun 13;13(6):722.\|Arch Pharm (Weinheim). 2025 Feb;358(2):e2400807.\|Cancer Res. 2022 Sep 2;82(17):3032-3044.\|Cell Chem Biol. 2021 Feb 16;S2451-9456(21)00051-9.\|Cell Metab. 2020 Apr 7;31(4):862-877.e14.\|Genome Biol. 2016 Jun 29;17(1):140. \|J Steroid Biochem Mol Biol. 2015 Aug;152:34-44.\|Sci China Life Sci. 2021 May 27;1-21.\|Cell Death Dis. 2021 May 13;12(5):482.\|Cell Rep. 2020 Aug 4;32(5):107944.\|Nat Chem Biol. 2016 Jul;12(7):497-503. \|University of Toronto. Department of Medical Biophysics
Smiles	CCN(C/C=C/C#CC(C)(C)C)CC1=CC=CC(OCC2=CC(C3=CSC=C3)=CS2)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	COX
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	449.67
Product Description	NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation
Clinical information	No Development Reported

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HY-16343-25mg-safety-datasheet.pdf