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Cyproheptadine (hydrochloride sesquihydrate)

Cyproheptadine (hydrochloride sesquihydrate)

ArtNr	HY-B1165-25g
Hersteller	MedChem Express
CAS-Nr.	41354-29-4
Menge	25 g
Quantity options	100 mg 10 g 10 mM/1 mL 1 g 25 g 500 mg 50 mg 5 g
Kategorie	Food Safety Drugs Histamines Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.82
Citations	[1]Feng YM, et al. Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase. BMC Cancer. 2015 Mar 17;15:134.\|[2]Mao X, et al. Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood. 2008 Aug 1;112(3):760-9.\|[3]Kacar S, et al. Cyproheptadine causes apoptosis and decreases inflammation by disrupting thiol/disulfide balance and enhancing the levels of SIRT1 in C6 glioblastoma cells. Toxicol In Vitro. 2021 Jun;73:105135. \|[4]Hsieh HY, et al. Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways. Cancer Lett. 2016 Jan 1;370(1):56-65.\|[5]He YL, et al. Cyproheptadine enhances the I(K) of mouse cortical neurons through sigma-1 receptor-mediated intracellular signal pathway. PLoS One. 2012;7(7):e41303.\|[6]Shannar A, et al. Cyproheptadine inhibits in vitro and in vivo lung metastasis and drives metabolic rewiring. Mol Biol Rep. 2024 Nov 10;51(1):1139.\|[7]Singh D, et al. Proconvulsant potential of cyproheptadine in experimental animal models. Fundam Clin Pharmacol. 2010 Aug;24(4):451-5.\|[8]He YL, et al. Cyproheptadine Regulates Pyramidal Neuron Excitability in Mouse Medial Prefrontal Cortex. Neurosci Bull. 2018 Oct;34(5):759-768.\|[9]Cakici I, et al. Hypoglycaemic effect of Momordica charantia extracts in normoglycaemic or cyproheptadine-induced hyperglycaemic mice. J Ethnopharmacol. 1994 Oct;44(2):117-21. Front Pharmacol. 2021 Apr 12;12:634097.\|Cureus. 2023 Nov 27;15(11):e49530.\|PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681.
Smiles	CN1CC/C(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C/24.[H]Cl.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor; Histamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	350.88
Product Description	Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine2.
Manufacturer - Research Area	Cancer; Endocrinology; Metabolic Disease; Neurological Disease
Solubility	DMSO: 33.33 mg/mL (ultrasonic)\|H2O: 0.67 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	α-1 microglobulin
Clinical information	Launched

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HY-B1165-25g-safety-datasheet.pdf