Emodin-8-glucoside

ArtNr	HY-N0311-50mg
Hersteller	MedChem Express
CAS-Nr.	23313-21-5
Menge	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.35
Citations	[1]Kim J M, et al. Constituents of the fruits of Rumex japonicus with Inhibitory Activity on Aldose Reductase[J]. Journal of Applied Biological Chemistry, 2008, 51(1): 13-16.\|[2]Hwangbo K, et al., Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica. Arch Pharm Res. 2012 Sep;35(9):1583-9.\|[3]Wang C, et al., Neuroprotective effects of emodin-8-O-beta-D-glucoside in vivo and in vitro. Eur J Pharmacol. 2007 Dec 22;577(1-3):58-63.\|[4]Zhang K, et al., Discovery of Natural Products Alleviating Renal Fibrosis with a Viscosity-Responsive Molecular Probe. Anal Chem. 2024 Apr 23;96(16):6356-6365.\|[5]Vaziri-Amjad S, et al., Natural anthraquinones as promising MAPK3 inhibitors for complementary cancer therapy[J]. Journal of Chemistry, 2023, 2023(1): 6683470.
Smiles	O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C13)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Aldose Reductase; p38 MAPK; SOD; Topoisomerase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	432.38
Product Description	Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier[1][2][3][4][5].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 50 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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