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Sivelestat (sodium tetrahydrate)

Sivelestat (sodium tetrahydrate)

ArtNr	HY-17443B-5mg
Hersteller	MedChem Express
CAS-Nr.	201677-61-4
Menge	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.\|[2]Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19(2):237-43.\|[3]Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311(1-2):87-92.\|[4]Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Aug 28. Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.\|Oxid Med Cell Longev. 2019 Nov 23;2019:7323986.\|Biofabrication. 2021 Feb 1.\|Brain Behav Immun. 2024 Jun 12:120:403-412.\|Burns Trauma. 17 September 2021.\|Cancers (Basel). 2022, 14(3), 515.\|Cell Biosci. 2022 Jul 22;12(1):114.\|Ecotoxicol Environ Saf. 2023 Nov 18:268:115694.\|Elife. 2022 Mar 23:11:e77444.\|Exp Mol Med. 2024 Dec 2.\|FASEB J. 2024 Dec 15;38(23):e70238.\|Heliyon. 2024 Oct 5;10(19):e38895.\|J Cell Mol Med. 2022 Feb 11.\|J Exp Med. 2023 Sep 4;220(9):e20221751.\|J Infect Dis. 2023 Nov 28:jiad526.\|Nat Commun. 2025 Feb 5;16(1):1378.\|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.\|Res Sq. 2024 Jul 30.\|Research Square Preprint. 2021 Aug.\|Research Square Preprint. 2021 Jun.\|Research Square Preprint. 2023 Dec 11.\|J Hepatocell Carcinoma. 2021 May 20;8:451-465.\|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.
Smiles	CC(C)(C)C(OC1=CC=C(S(=O)(NC2=CC=CC=C2C(NCC(O[Na])=O)=O)=O)C=C1)=O.O.O.O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	EI546 (sodium tetrahydrate),LY544349 (sodium tetrahydrate),ONO5046 (sodium tetrahydrate)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Elastase; SARS-CoV
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	528.51
Product Description	Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Metabolic Enzyme/Protease
Clinical information	Launched

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HY-17443B-5mg-safety-datasheet.pdf