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Thioridazine-d3 2-Sulfone

Thioridazine-d3 2-Sulfone

ArtNr	HY-B0965S-10mg
Hersteller	MedChem Express
CAS-Nr.	1329652-09-6
Menge	10 mg
Quantity options	10 mg 1 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Molecules
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. \|[2]Tschanz JT, et, al. Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy. Pharmacol Biochem Behav. 1988 Nov;31(3):519-22.\|[3]Mu J, et, al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. Oncol Rep. 2014 May;31(5):2107-14.\|[4]Aguilar-Vega L, et, al. Antibacterial properties of phenothiazine derivatives against multidrug-resistant Acinetobacter baumannii strains. J Appl Microbiol. 2021 Apr 22.\|[5]Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17(9):989-97.\|[6]Loehr AR, et, al. Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors. Cancers (Basel). 2021 Apr 23;13(9):2045.
Smiles	C(CC1N(C([2H])([2H])[2H])CCCC1)N2C=3C(SC=4C2=CC=CC4)=CC=C(S(C)(=O)=O)C3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	5-HT Receptor; Apoptosis; Autophagy; Bacterial; Dopamine Receptor; Isotope-Labeled Compounds
Shipping Temperature	Room temperature
Molecular Weight	405.59
Product Description	Thioridazine-d3 2-Sulfone is the deuterium labeled Thioridazine hydrochloride. Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].
Manufacturer - Research Area	Cancer; Infection; Neurological Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling; Others
Isoform	D3 Receptor
Clinical information	No Development Reported

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Menge: 10 mg

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