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DAPI (dihydrochloride)

DAPI (dihydrochloride)

ArtNr	HY-D0814-1mg
Hersteller	MedChem Express
CAS-Nr.	28718-90-3
Menge	1 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.67
Citations	[1]Kapuscinski J, et al. DAPI: a DNA-specific fluorescent probe. Biotech Histochem. 1995 Sep;70(5):220-33. ACS Appl Bio Mater. 2021 Jan 6.\|ACS Appl Mater Interfaces. 2025 Feb 19.\|ACS Nano. 2023 Jul 3.\|Acta Biochim Biophys Sin (Shanghai). 2021 Nov 10;53(11):1558-1566.\|Acta Biomater. 2019 Sep 15;96:468-479.\|Acta Pharmacol Sin. 2021 Jul;42(7):1111-1123.\|Adv Funct Mater. 2022: 2204636.\|Adv Healthc Mater. 2025 Jan 22:e2404642.\|Adv Sci (Weinh). 2024 Dec 12:e2410495.\|Adv Sci (Weinh). 2024 Jun 21:e2400952.\|Autophagy. 2021 Dec 29;1-13.\|Biochem Pharmacol. 2023 Jul 21;115699.\|Biol Direct. 2024 Dec 24;19(1):135.\|Biomed Pharmacother. 2023 Aug 30;166:115399.\|Biomed Pharmacother. 2024 Oct 24:180:117606.\|Biomolecules. 2025 Feb 1.\|bioRxiv. 2024 Dec 23:2024.12.22.627112.\|bioRxiv. 2024 Dec 23:2024.12.22.629999.\|bioRxiv. 2024 November 29.\|bioRxiv. 2025 January 13.\|Cancer Lett. 2021 Apr 28;504:125-136.\|Cancer Nanotechnol. 2024 Feb 22.\|Cell Death Differ. 2024 May 23.\|Cell Death Discov. 2024 Nov 1;10(1):462.\|Cell Prolif. 2024 Sep 27:e13732.\|Cell Rep. 2023 Jul 8;42(7):112789.\|Cell Rep. 2024 Aug 30;43(9):114652.\|Cell Res. 2022 Dec;32(12):1047-1067.\|Cell Tissue Res. 2023 Mar 6.\|Chem Biol Interact. 2023 Aug 28, 110681.\|Chem Biol Interact. 2023 Aug 28;110684.\|Compos B Eng. 2024 Jul 15.\|Ecotoxicol Environ Saf. 2023 Apr 24;257:114940.\|Eur J Med Chem. 2024 Dec 5:279:116866.\|Eur J Med Chem. 2024 May 17:273:116507\|Front Cell Dev Biol. 2021 Apr 15;9:665869.\|Front Oncol. 2022 Mar 25;12:773654.\|Glia. 2022 Feb;70(2):337-353.\|Int Immunopharmacol. 2024 Jun 18:137:112431.\|Int J Biol Macromol. 2024 Jul 4:133652.\|J Adv Res. 2024 Oct 5:S2090-1232(24)00432-6.\|J Biomed Sci. 2024 May 13;31(1):50.\|J Clin Invest. 2024 Oct 22:e182217.\|J Control Release. 2025 Feb 19:380:829-845.\|J Ethnopharmacol. 2022 Oct 21;115855.\|J Immunother Cancer. 2025 Feb 6;13(2):e010150.\|J Neuropathol Exp Neurol. 2020 Jul 1;79(7):734-745.\|J Nucl Med. 2021 Oct 28;jnumed.121.262743.\|J Oral Biosci. 2024 Sep 6:S1349-0079(24)00198-1.\|Kaohsiung J Med Sci. 2022 Apr;38(4):357-366.\|Light Sci Appl. 2022 Nov 11;11(1):324.\|Microb Pathog. 2023 Dec 30:106527.\|Mol Med Rep. 2021 Dec;24(6):832.\|Mol Nutr Food Res. 2022 Apr;66(7):e2101088.\|Nat Commun. 2023 Aug 22;14(1):5111.\|Nat Commun. 2024 Aug 10;15(1):6845.\|Nat Commun. 2024 Sep 1;15(1):7603.\|Nat Methods. 2023 Nov 30.\|Oncotargets Ther. 2020 Oct 6;13:9941-9952.\|Pathog Dis. 2024 May 31:ftae011.\|Pharmaceuticals. 2022 Jun 6;15(6):721.\|Phytomedicine. 2020 Mar;68:153146.\|Res Sq. 2024 Jul 29.\|Research (Wash D C). 2024 Sep 12:7:0472.\|Research Square Preprint. 2023 Oct 24.\|Research Square Preprint. 2024 Dec 04.\|Research Square Print. 2023 Feb 2.\|SSRN. 2023 May 10.\|SSRN. 2023 Sep 6.\|SSRN. 2024 Jun 21.\|Cell Death Discov. 2024 Oct 5;10(1):429.\|Discov Oncol. 2025 Jan 9;16(1):27.
Smiles	N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(C(N)=N)C=C3)N2)N.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	4',6-Diamidino-2-phenylindole dihydrochloride
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Dye Reagents
Manufacturer - Targets	DNA Stain
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	350.25
Product Description	DAPI dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells[1].
Manufacturer - Research Area	Others
Solubility	DMSO: 75 mg/mL (ultrasonic)\|H2O: 5.56 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	No Development Reported

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HY-D0814-1mg-safety-datasheet.pdf