ArtNr |
HY-P74417-200ug |
Hersteller |
MedChem Express
|
Menge |
200 ug |
Quantity options |
100 ug
10 ug
200 ug
2 ug
500 ug
50 ug
|
Kategorie |
|
Typ |
Peptides |
Specific against |
other |
Purity |
97.00 |
Sequence |
LSPGLKCVCL LCDSSNFTCQ TEGACWASVM LTNGKEQVIK SCVSLPELNA QVFCHSSNNV TKTECCFTDF CNNITLHLPT ASPNAPKLGP ME |
Citations |
[1]M Rydén, et al. A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system. J Biol Chem. 1996 Nov 29;271(48):30603-9. [2]Byung-Chul Kim, et al. Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells. J Biol Chem. 2004 Jul 2;279(27):28458-65. [3]Wen-bo Li, et al. Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats. Acta Diabetol. 2015 Aug;52(4):717-26. [4]Kunihiro Tsuchida, et al. Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Mol Cell Endocrinol. 2004 May 31;220(1-2):59-65. |
Smiles |
LSPGLKCVCL LCDSSNFTCQ TEGACWASVM LTNGKEQVIK SCVSLPELNA QVFCHSSNNV TKTECCFTDF CNNITLHLPT ASPNAPKLGP ME |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
ALK-7 Protein, Human (HEK293, Fc),Human,HEK293 |
Versandbedingung |
Gekühlt |
Lieferbar |
|
Manufacturer - Type |
Recombinant Proteins |
Shipping Temperature |
Blue Ice |
Storage Conditions |
Stored at -20°C for 2 years |
Molecular Weight |
The recombinant human ALK-7 consists of 92 amino acids & hFc tag and predicts a molecular mass of 35.96 kDa. It migrates as an approximately 43-56 kDa band in SDS-PAGE under reducing conditions. |
Product Description |
ALK-7 is a type I receptor serine-threonine kinase mediate inhibitory as well as stimulatory signals for growth and differentiation by binding to members of the TGF-β superfamily. ALK-7 combined with specific ligands, such as Nodal, activin B and growth differentiation factor (GDF), can activate Smads and other signaling pathways, thereby regulating cell proliferation, differentiation and apoptosis in various cells[1][2][3]. ALK-7 Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 113 amino acids (M1-E113). |
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