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BMPRIB/ALK-6, Mouse (HEK293, Fc)

BMPRIB/ALK-6, Mouse (HEK293, Fc)

ArtNr	HY-P76176-10ug
Hersteller	MedChem Express
Menge	10 ug
Quantity options	100 ug 10 ug 1 ea 20 ug 500 ug 50 ug 5 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Purity	96.00
Sequence	KKEDGESTAP TPRPKILRCK CHHHCPEDSV NNICSTDGYC FTMIEEDDSG MPVVTSGCLG LEGSDFQCRD TPIPHQRRSI ECCTERNECN KDLHPTLPPL KDRDFVDGPI HHK
Citations	[1]ten Dijke P, et al. Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Curr Opin Cell Biol. 1996 Apr;8(2):139-45.\|[2]Xu H, et al. [BMP7 signaling via BMPR1A, BMPR1B inhibits the proliferation of lung large carcinoma NCI-H460 cell]. Zhongguo Fei Ai Za Zhi. 2010 Jul;13(7):659-64. Chinese.\|[3]Demirhan O, et al. A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies. J Med Genet. 2005 Apr;42(4):314-7.\|[4]Lin YC, et al. SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. Am J Hum Genet. 2021 Jan 7;108(1):115-133.\|[5]Yang CX, et al. Cloning and mRNA expression levels of GDF9, BMP15, and BMPR1B genes in prolific and non-prolific goat breeds. Mol Reprod Dev. 2012 Jan;79(1):2.\|[6]Yoon BS, et al. Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5062-7.\|[7]Renault L, et al. BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency. J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgz226.
Smiles	KKEDGESTAP TPRPKILRCK CHHHCPEDSV NNICSTDGYC FTMIEEDDSG MPVVTSGCLG LEGSDFQCRD TPIPHQRRSI ECCTERNECN KDLHPTLPPL KDRDFVDGPI HHK
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	BMPRIB/ALK-6 Protein,Mouse (HEK293,Fc),Mouse,HEK293
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	Approximately 39.4 kDa.
Product Description	BMPR1B/ALK-6 protein is a type I member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases[1]. BMPR1B/ALK-6 is the receptor for BMP-7/OP-1 and GDF-5, positively regulates chondrocyte differentiation through GDF-5 interaction[2][3]. BMPR1B/ALK-6 also involves in SCUBE3/BMP-2/BMP-4 signals regulation, controlling growth, morphogenesis, and bone and teeth development[4]. ALK-6/GDF-9/BMP-15 signals is essential in prolificacy of goat[5]. The mouse BMPR1B/ALK-6 protein contains 502 amino acids and a transmembrane domain (127-148 a.a.). BMPRIB/ALK-6 Protein, Mouse (HEK293, Fc) is produced by HEK293 cells (K14-K126) with C-terminal hFc-tag.

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Menge: 10 ug

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