Oxfenicine

ArtNr	HY-W018026-500mg
Hersteller	MedChem Express
CAS-Nr.	32462-30-9
Menge	500 mg
Quantity options	100 mg 10 mM/1 mL 500 mg 5 g
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Stephens TW, et, al. Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine. Biochem J. 1985 Apr 15;227(2):651-60.\|[2]Greaves P, et, al. Cardiac hypertrophy in the dog and rat induced by oxfenicine, an agent which modifies muscle metabolism. Arch Toxicol Suppl. 1984;7:488-93.\|[3]Kennedy JA, et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol. 2000 Dec;36(6):794-801.\|[4]Sepa-Kishi DM, et al. Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1;311(4):R779-R787.\|[5]Kong JY, et al. Palmitate-induced cardiac apoptosis is mediated through CPT-1 but not influenced by glucose and insulin. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H717-25.
Smiles	O=C(O)[C@@H](N)C1=CC=C(O)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	L-p-Hydroxyphenylglycine,4-Hydroxy-L-phenylglycine,UK 25842
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Acyltransferase; Apoptosis
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	167.16
Product Description	Oxfenicine (L-p-Hydroxyphenylglycine) is an orally active carnitine palmitoyltransferase-1 inhibitor. Oxfenicine inhibits the oxidation of fatty acids in the heart, protecting cardiac tissue from necrotic damage during ischemia, and also has an inhibitory effect on cardiac tissue apoptosis. In addition, Oxfenicine promotes lipolysis in a high-fat diet rat model. Oxfenicine can be used in the study of cardiovascular and metabolic diseases[1][2][3][4][5].
Manufacturer - Research Area	Metabolic Disease; Cardiovascular Disease
Solubility	DMSO: < 1 mg/mL (ultrasonic)\|H2O: 4.55 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-W018026-500mg-safety-datasheet.pdf