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SWAP70 Antibody (Ascites) [AMM02404G]

SWAP70 Antibody (Ascites) [AMM02404G]

ArtNr	LBI-AMM02404G
Hersteller	Leading Biology
Menge	100 ul
Quantity options	100 ul
Kategorie	Antibodies Western Blot ELISA Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB
Clon	434CT16.5.5
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Switch-associated protein 70, SWAP-70, SWAP70, KIAA0640
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Manufacturer - Type	Monoclonal Antibodies
Manufacturer - Category	Abs-G
Storage Conditions	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight	68998
Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality SWAP70 Antibody (Ascites) [AMM02404G].
Manufacturer - Specificity	Purified His-tagged SWAP70 protein(Fragment) was used to produced this monoclonal antibody.
Cellular localization	Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448) In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).
Gene Name	SWAP70
Function	Phosphatidylinositol 3, 4, 5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3, 4)-bisphosphate production and cell protrusion (By similarity).
Summary	Tissue Location: Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
Manufacturer - Format	Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Dilution	WB-1:1000~8000
Clonality	Monoclonal

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100 ul

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Lieferung vsl. bis 18.09.2025

Express-Lieferung: 15 Tage sparen

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