STK16-IN-1

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-101270-10mM
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
CAS No.
1223001-53-3
Purity
>98%
MW
2932950832
Formula
C17H12FN3O
Solubility
DMSO: 15 mg/mL
Biological Description
STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.
IC50 & Target: IC50: 295 nM (STK16)[1]
In Vitro: STK16-IN-1, which exhibits potent inhibitory activity against STK16 kinase (IC50=0.295 uM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 inhibits mTOR kinase with an IC50 of 5.56 uM. In MCF-7 cells, treatment with STK16-IN-1 results in a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16)[1].
Free  Sample
Available in quantities of 0, 5mg-1mg. Three different samples per customer per year!
Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 140,00 €
Preis: 140,00 €
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