Rucaparib

ArtNr	HY-10617A-10mg
Hersteller	MedChem Express
CAS-Nr.	283173-50-2
Menge	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 200 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Thomas HD, et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther, 2007, 6(3), 945-956.\|[2]Hunter JE, et al. NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699. Oncogene, 2012, 31(2), 251-264.\|[3]Daniel RA, et al. Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. Clin Cancer Res, 2009, 15(4), 1241-1249.\|[4]Matt Shirley, et al. Rucaparib: A Review in Ovarian Cancer. Target Oncol. 2019 Apr;14(2):237-246.\|[5]J Murray, et al. Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules. Br J Cancer. 2014 Apr 15;110(8):1977-84.\|[6]Jianneng Li, et al. Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation. Sci Transl Med. 2021 May 26;13(595):eabe8226. Aging. 2021 Jan 20;13(3):4242-4257.\|Am J Cancer Res. 2020 Aug 1;10(8):2649-2676.\|Am J Cancer Res. 2024 Jan 15;14(1):378-389.\|bioRxiv. 2023 Feb 6.\|bioRxiv. 2023 Feb 7.\|bioRxiv. 2024 Jul 10:2024.07.09.602803.\|bioRxiv. 2024 September 19.\|BMC Cancer. 2022 Mar 23;22(1):312.\|Cancers (Basel). 2024 Nov 5;16(22):3728.\|Clin Cancer Res. 2017 Feb 15;23(4):1001-1011. \|DNA Repair (Amst). 2019 Jan;73:64-70.\|Eur J Nucl Med Mol Imaging. 2024 Jul 18.\|FASEB J. 2022 Jul;36(7):e22418.\|Front Oncol. 2021 Jul 9;11:681441.\|Gene. 2020 Oct 30;759:145000.\|Genes Dis. 2023 Apr 12.\|Int J Mol Sci. 2020 Feb 11;21(4):1185.\|JCI Insight. 2023 Nov 8;8(21):e165268.\|Mol Cancer Ther. 2024 Jun 19.\|Nat Methods. 2023 Sep;20(9):1388-1399.\|Neoplasia. 2025 Mar 16:63:101152.\|Neurooncol Adv. 2023 Feb 10;5(1):vdad010.\|Patent. US20180263995A1.\|Patent. US20180362972A1.\|Research Square Preprint. 2024 Nov 06.\|Research Square Print. September 20th, 2022.\|Research Square Print. September 22nd, 2022.\|Sci Adv. 2022 Feb 18;8(7):eabl9794.\|Sci Immunol. 2024 Mar 15;9(93):eadj7238.\|Sci Transl Med. 2021 May 26;13(595):eabe8226.\|Talanta. 2018 Apr 1;180:127-132.\|Theranostics. 2020 Jul 25;10(21):9477-9494. \|Analyst. 2018 May 29;143(11):2501-2507.\|Biochem Biophys Res Commun. 28 September 2021.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|Nat Cell Biol. 2024 Jul 12.\|Patent. US20200078369A1\|Patent. US20200129476A1\|PLoS One. 2024 Nov 1;19(11):e0308647.\|Sens Actuators B Chem. 2018 Nov 10; 273:1047-1053.\|Sens Actuators B Chem. 2018, 259: 565-572.\|J Med Chem. 2023 Mar 6.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
Smiles	FC1=CC2=C3C(CCNC2=O)=C(C4=CC=C(CNC)C=C4)NC3=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AG014699,PF-01367338
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	PARP
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	323.36
Product Description	Rucaparib (AG014699) is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib has the potential for castration-resistant prostate cancer (CRPC) research[1][2][3][4].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 70 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics
Isoform	PARP1; PARP2; PARP3
Clinical information	Launched

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HY-10617A-10mg-safety-datasheet.pdf