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3-Methylglutaric acid

3-Methylglutaric acid

ArtNr	HY-113410-1g
Hersteller	MedChem Express
CAS-Nr.	626-51-7
Menge	1 g
Quantity options	10 mM/1 mL 1 g 500 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Ribeiro CA, et al. Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+,K+-ATPase activity probably through oxidative damage in brain cortex of young rats. Int J Dev Neurosci. 2011 Feb;29(1):1-7.\|[2]da Rosa-Junior NT, et al. In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver. Biochimie. 2020 Apr-May;171-172:187-196.\|[3]da Rosa-Junior NT, et al. Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats. Neurotox Res. 2019 May;35(4):809-822.\|[4]Colín-González AL, et al. Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms. Neurochem Res. 2016 Oct;41(10):2619-2626.
Smiles	O=C(O)CC(C)CC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	626-51-7
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Targets	Mitochondrial Metabolism; Na+/K+ ATPase; Reactive Oxygen Species (ROS)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	146.14
Product Description	3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration[1][2][3][4].
Manufacturer - Research Area	Metabolic Disease; Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 100 mg/mL
Manufacturer - Pathway	Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB
Isoform	Human Endogenous Metabolite
Clinical information	No Development Reported

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HY-113410-1g-safety-datasheet.pdf