WS6

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Menge 10mM*1mL (in DMSO)
ArtNr HY-12461-10mM
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
WS-6, WS 6
CAS No.
1421227-53-3
Purity
>98%
MW
568.59
Formula
C29H31F3N6O3
Solubility
10 mM in DMSO
Biological Description
WS6 is a novel small molecule that promotes beta cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).
EC50 value: 0.28 uM [1]
Target: beta cell proliferation agonist
in vitro: WS6 induced up to 4% of rat beta cells to proliferate, with an EC50 of 0.4 uM. In the same format, WS6 also induced 3% of human beta cells to proliferate, with a similar potency to the rat beta cells. WS6 induced R7T1 proliferation in dose response, with EC50 value of 0.28 uM, Proliferation of R7T1 cells, which are cultured in suspension and grow as clusters, was apparent by visible inspection.
in vivo: RIP-DTA mice were fed Dox in the drinking water until the onset of overt diabetes (blood glucose reading >300 mg/dL, typically 4-10 days), at which point Dox treatment was discontinued and treatment with WS6 was initiated (5 mg/kg every other day via intraperitoneal injection). Pharmacokinetic studies with WS6 at 50 mg/kg revealed a CMAX of ca.5 uM and T1/2 of ca.2 h. Treatment with WS6 caused a progressive reduction of blood glucose over time, starting around 2 weeks.
Menge: 10mM*1mL (in DMSO)
Lieferbar: In stock
Listenpreis: 152,86 €
Rabatt: -10,0%
Preis: 137,57 €
Sie sparen: 15,29 €
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