Talazoparib

ArtNr	HY-16106-10mM
Hersteller	MedChem Express
CAS-Nr.	1207456-01-6
Menge	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 200 mg 50 mg 5 mg
Kategorie	Oncology Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer
Typ	Inhibitors
Specific against	other
Purity	99.89
Citations	[1]Wang B, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent. J Med Chem. 2016 Jan 14;59(1):335-57.\|[2]Shen Y, et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.Clin Cancer Res. 2013 Sep 15;19(18):5003-15. ACS Appl Mater Interfaces. 2019 Apr 3;11(13):12342-12356. \|Adv Sci (Weinh). 2024 Jul 8:e2400140.\|Adv Sci (Weinh). 2024 Mar 14:e2307940.\|Am J Cancer Res. 2020 Aug 1;10(8):2649-2676.\|Am J Cancer Res. 2024 Jan 15;14(1):378-389.\|Biochem Pharmacol. 2025 Feb 28:116843.\|Bioeng Transl Med. 2019 Jun 14;4(2):e10131. \|Bioinformatics. 2022 Jul 26;btac533.\|Biomed Res Int. 2023 Feb 6.\|bioRxiv. 2023 Apr 17.\|bioRxiv. 2023 Jun 22.\|bioRxiv. 2023 Jun 28.\|bioRxiv. 2024 Jul 10:2024.07.09.602803.\|bioRxiv. 2024 Nov 26:2024.11.21.624591.\|bioRxiv. April 22, 2021.\|BMC Cancer. 2022 Mar 23;22(1):312.\|Br J Cancer. 2024 May 28.\|Cancer Cell Int. 2023 Jun 27;23(1):128.\|Cancer Cell. 2020 Dec 14;38(6):844-856.e7.\|Cancer Discov. 2017 Sep;7(9):984-998.\|Cancer Discov. 2022 May 12;candisc.1181.2021.\|Cancer Lett. 2021 Jan 22;S0304-3835(21)00024-0.\|Cancer Lett. 2021 Mar 1;500:208-219.\|Cancer Lett. 2022 Aug 1;215851.\|Cancer Res. 2021 Jun 14.\|Cancer Res. 2023 Sep 11.\|Cell Biosci. 2024 Feb 6;14(1):20.\|Cell Rep. 2023 Oct 16;42(10):113256.\|Cell Rep. 2024 Jul 18;43(8):114522.\|Clin Cancer Res. 2017 Feb 15;23(4):1001-1011. \|Data Brief. 22 September 2021, 107394.\|Département de Pharmacologie et Physiologie, Faculté de Médecine. 2020 Jun.\|Drug Des Devel Ther. 2020 Feb 25;14:783-793.\|EBioMedicine. 2018 Dec;38:47-56. \|EBioMedicine. 2020 Sep;59:102923.\|Front Oncol. 2021 Jul 9;11:681441.\|Genes (Basel). 2023 Jun 20, 14(6), 1295.\|Int J Cancer. 2024 Apr 15.\|Int J Mol Sci. 2022, 23(22), 14338\|Int J Mol Sci. 2020 Feb 11;21(4):1185.\|Integr Biol (Camb). 2019 Apr 1;11(4):130-141.\|Invest New Drugs. 2021 Mar 12.\|J Clin Invest. 2021 Jun 1;131(11):146256.\|J Med Chem. 2023 Aug 21.\|J Pers Med. 2023 Aug 27, 13(9), 1315.\|Methods Mol Biol. 2018;1711:351-398.\|Mol Cell. 2017 May 18;66(4):503-516.e5. \|Nat Cancer. 2022 Oct;3(10):1211-1227.\|Nat Commun. 2023 Dec 9;14(1):8161.\|Nat Commun. 2019 Jun 11;10(1):2556. \|Nat Genet. 2022 Dec;54(12):1983-1993.\|Neoplasia. 2019 Jul 27;21(9):863-871.\|NPJ Precis Oncol. 2025 Mar 12;9(1):69.\|Oncogene. 2017 Aug 17;36(33):4682-4691.\|Oncogene. 2021 Sep 10.\|Oncogenesis. 2025 Mar 1;14(1):4.\|Oncol Lett. 2025 January 7.\|Oncol Rep. 2019 Nov;42(5):2097-2107.\|Oxid Med Cell Longev. 14 Jul 2022.\|Patent. US20180263995A1.\|Patent. US20180362972A1.\|Patent. US20200078369A1\|Patent. US20200129476A1\|Patent. US20210030680A1.\|Patent. US20220054606A1.\|PLoS One. 2024 Apr 16;19(4):e0302130.\|Radiother Oncol. 2021 Jan 29;157:175-181.\|Research Square Preprint. 2024 Feb 2.\|Research Square Print. January 4th, 2023.\|Sci Adv. 2022 Feb 18;8(7):eabl9794.\|Sci Rep. 2023 Feb 27;13(1):3334.\|Theranostics. 2020 Jul 25;10(21):9477-9494. \|University of London. 2021 Sep.\|University of Pittsburgh. 2024.\|DNA Repair (Amst). 2019 Jan;73:64-70.
Smiles	O=C1NN=C2C3=C1C=C(F)C=C3N[C@H](C4=CC=C(F)C=C4)[C@H]2C5=NC=NN5C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BMN-673,LT-673
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	PARP
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	380.35
Product Description	Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics
Isoform	PARP1; PARP2
Clinical information	Launched

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HY-16106-10mM-safety-datasheet.pdf