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Elacestrant (dihydrochloride)

Elacestrant (dihydrochloride)

ArtNr	HY-19822A-50mg
Hersteller	MedChem Express
CAS-Nr.	1349723-93-8
Menge	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer
Typ	Inhibitors
Specific against	other
Purity	99.72
Formula	C30H40Cl2N2O2
Citations	Cancer Discov. 2023 Nov 20. J Med Chem. 2020 Oct 8;63(19):11085-11099. Mol Cancer Ther. 2020 Jul;19(7):1395-1405. Biomed Pharmacother. 2024 Oct 14:180:117523. bioRxiv. 2023 Nov 2. bioRxiv. 2024 Jun 2:2024.05.28.596307. Harvard University. 2023 Mar. 30487357. J Cell Mol Med. 2023 Aug 18. NPJ Breast Cancer. 2022 Dec 14;8(1):130. Res Sq. 2024 Jun 04. Research Square Preprint. 2023 May 9. Research Square Preprint. 2024 Nov 06. [1]Garner F, et al. RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models. Anticancer Drugs. 2015 Oct;26(9):948-56. [2]Bihani T, et al. Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER+ Breast Cancer Patient-derived Xenograft Models. Clin Cancer Res. 2017 Aug 15;23(16):4793-4804.
Smiles	OC1=CC=C2C[C@H](C3=CC=C(OC)C=C3N(CC)CC4=CC=C(CCNCC)C=C4)CCC2=C1.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	RAD1901 dihydrochloride
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Estrogen Receptor/ERR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	531.56
Product Description	Elacestrant (RAD1901) dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant dihydrochloride also can inhibit growth of ER+ breast cancer cell lines in vitro and in vivo[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Vitamin D Related/Nuclear Receptor
Clinical information	Launched

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HY-19822A-50mg-safety-datasheet.pdf