Verapamil (hydrochloride)

Hersteller MedChem Express
Kategorie
Typ Inhibitors
Specific against other
Clon N/A
Menge 10mM*1mL (in DMSO)
ArtNr HY-A0064-10mM
eClass 6.1 30220300
eClass 9.0 32160605
Lieferbar
Synonyms
(+/-)-Verapamil hydrochloride
CAS No.
152-11-4
Purity
>98%
MW
4910626
Formula
C27H39ClN2O4
Solubility
DMSO: >= 31 mg/mL
Biological Description
Verapamil hydrochloride is an L-type calcium channel antagonist.
IC50 & Target: Calcium channel[1]
In Vitro: Verapamil (hydrochloride) is an L-type calcium channel antagonist. The combination of Bortezomib and Verapamil (70 uM) markedly declines the viability of the JK-6L, RPMI 8226, and ARH-77 cell lines after 16 hours of culture[1]. The enzyme hydrolase activity of recombinant human carboxylesterase (CES2) is substantially inhibited by Verapamil with Ki of 3.84+/-0.99uM[2].
In Vivo: Verapamil, a calcium channel antagonist, is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia (P<0.01 vs. sham). Verapamil (1 mg/kg) significantly prevented the enhancement of total arrhythmia scores induced by ischemia (P<0.01 vs. ischemia). Results indicate that Verapamil exerts an anti-arrhythmic property[3].
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Menge: 10mM*1mL (in DMSO)
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