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Tolazoline (hydrochloride)

Tolazoline (hydrochloride)

ArtNr	HY-A0066A-10mM
Hersteller	MedChem Express
CAS-Nr.	59-97-2
Menge	10 mM/1 mL
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Kategorie	Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Megens AA, et al. Further validation of in vivo and in vitro pharmacological procedures for assessing the alpha 2/alpha 1-selectivity of test compounds: (1). Alpha-adrenoceptor antagonists. Eur J Pharmacol. 1986 Sep 23;129(1-2):49-55.\|[2]Schwartz DD, et al. Selectivity of atipamezole, yohimbine and tolazoline for alpha-2 adrenergic receptor subtypes: implications for clinical reversal of alpha-2 adrenergic receptor mediated sedation in sheep. J Vet Pharmacol Ther. 1998 Oct;21(5):342-7.\|[3]Costa P, et al. Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum. J Urol. 1993 Sep;150(3):859-63. \|[4]Rogers RA, et al. Pharmacologic modulation of the cutaneous vasculature in the isolated perfused porcine skin flap. J Pharm Sci. 1994 Dec;83(12):1682-9.\|[5]Lei L, et al. Activation of L-type calcium channel by tolazoline derivatives: role of isothiocyanate moiety. J Cardiovasc Pharmacol. 1998 May;31(5):721-33.\|[6]BENFEY BG, et al. VASOCONSTRICTOR ACTION OF TOLAZOLINE. Br J Pharmacol Chemother. 1964 Feb;22(1):66-71.\|[7]Hsu WH, et al. Effects of tolazoline and yohimbine on xylazine-induced central nervous system depression, bradycardia, and tachypnea in sheep. J Am Vet Med Assoc. 1987 Feb 15;190(4):423-6.
Smiles	[H]Cl.C1(CC2=CC=CC=C2)=NCCN1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Imidaline (hydrochloride),NSC35110 (hydrochloride)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Targets	Adrenergic Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	196.68
Product Description	Tolazoline hydrochloride (Imidaline hydrochloride) is an α-adrenergic receptor antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular disease research[1][2][3][4][5][6][7].
Manufacturer - Research Area	Endocrinology; Cardiovascular Disease
Solubility	DMSO: 33.33 mg/mL (ultrasonic)\|H2O: ≥ 50 mg/mL
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	Launched

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HY-A0066A-10mM-safety-datasheet.pdf