« Back
Home /
Amiloride hydrochloride dihydrate

Amiloride hydrochloride dihydrate

Item no.	HY-B0285B-100mg
Manufacturer	MedChem Express
CASRN	17440-83-4
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL
Category	Food Safety Proteins Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.85
Formula	C6H13Cl2N7O3
Citations	Transl Res. 2023 Sep 5;S1931-5244(23)00143-3. ACS Nano. 2023 Apr 14. Adv Funct Mater. 2024 Oct 31. Adv Sci (Weinh). 2023 Dec 14:e2307880. Am J Transl Res. 2021 Jul 15;13(7):7538-7555. Cell Commun Signal. 2023 May 4;21(1):99. Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. Cell Physiol Biochem. 2018;51(6):2564-2574. Commun Biol. 2022 Nov 14;5(1):1248. Environ Sci Technol. 2021 Feb 11. Int J Biol Macromol. 2024 Aug 5;277(Pt 3):134517. J Am Chem Soc. 2018 Dec 12;140(49):17234-17240. J Control Release. 2024 Oct 26:S0168-3659(24)00725-9. J Leukoc Biol. 2024 Jul 16:qiae159. J Nanobiotechnology. 2020 Jan 31;18(1):26. J Pharmaceut Biomed. 2020, 113870. Microb Pathog. 2019 Jul 18:103638. Nanotechnology. 2018 Feb 23;29(8):085101. Nat Biomed Eng. 2024 Sep 13. Nat Nanotechnol. 2024 Aug 26. Small Methods. 2020 Dec 18. Theranostics. 2019 May 31;9(13):3732-3753. Acta Pharm Sin B. 2024 Jul 27. Biomaterials. 2022 May;284:121529. Br J Pharmacol. 2020 Aug;177(15):3473-3488. Cell Mol Immunol. 2024 Jun 13. Cell Rep. 2022 May 31;39(9):110880. Food Chem. 2024 Sep 8;463(Pt 1):141196. Int J Biol Macromol. 14 March 2022. iScience. 19 October 2022, 105403. J Ethnopharmacol. 2022 Mar 5;115171. J Neuroinflammation. 2022 Feb 22;19(1):53. Sci Total Environ. 2021, 146523. Theranostics. 2020 May 17;10(15):6581-6598. [1]Miller RL, et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. [2]Xu LB, et al. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29. [3]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91.
Smiles	O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.[H]Cl.O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK-870 hydrochloride dihydrate
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Apoptosis; Sodium Channel; TRP Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	302.12
Product Description	Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
Manufacturer - Research Area	Metabolic Disease; Cardiovascular Disease
Solubility	DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 2 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-B0285B-100mg-safety-datasheet.pdf