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Diphenhydramine (hydrochloride)

Diphenhydramine (hydrochloride)

ArtNr	HY-B0303A-10mM
Hersteller	MedChem Express
CAS-Nr.	147-24-0
Menge	10 mM/1 mL
Quantity options	100 g 10 g 10 mM/1 mL 250 mg 25 g 500 mg 50 g 5 g
Kategorie	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10(5):350-380.\|[2]Sadiq MW, et al. Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo. J Pharm Sci. 2011;100(9):3912-3923.\|[3]Hamano H, et al. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney Int. 2021 Apr;99(4):885-899.\|[4]Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72.\|[5]Zhang R, Chen M, Yu L, et al. Anticancer activity of diphenhydramine against pancreatic cancer by stimulating cell cycle arrest, apoptosis, and modulation of PI3K/Akt/mTOR pathway[J]. Cell proliferation, 2021, 69: 5. bioRxiv. 2025 Sep 10:2025.09.05.673576. Cell Rep Methods. 2023 Oct 23;3(10):100599. Cell Rep. 2022 Nov 8;41(6):111615. Chemosphere. 2019 Jun:225:378-387. Pharmacol Res Perspect. 2021 Oct;9(5):e00879. Acta Pharmacol Sin. 2024 Oct;45(10):2061-2076. Pharm Res. 2025 Oct 27.
Smiles	CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	147-24-0
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Category	Reference compound / Active compounds; API; Natural Products
Manufacturer - Targets	Apoptosis; Bacterial; Endogenous Metabolite; Histamine Receptor
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	291.82
Product Description	Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].
Manufacturer - Research Area	Inflammation/Immunology; Endocrinology; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Clinical information	Launched
Isoform	H1 Receptor
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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