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Denatonium (benzoate)

Denatonium (benzoate)

ArtNr	HY-B1146-10mM
Hersteller	MedChem Express
CAS-Nr.	3734-33-6
Menge	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 1 g 500 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.92
Citations	[1]Plamen I Zagorchev, et al. Denatonium benzoate decreases the effect of histamine in vitro and in rats. Tropical Journal of Pharmaceutical Research September.2020; 19 (9): 1879-1885. \|[2]Huaping Xu, et al. Denatonium Benzoate Exposure Promotes IgE-Mediated Mast Cell Degranulation and Allergy By Upregulating FcεRIα Expression.Hypothesis. posted 29 Sep, 2021 \|[3]DALEE. KAUKEINEN, et al. Evaluation of aversive agents to increase the selectivity of rodenticides with emphasis on denatonium benzoate (Bitrex) bittering agent. eScholarship. Proceedings of the Vertebrate Pest Conference, 15(15)\|[4]Weikun Huang, et al. Effects of a bitter substance, denatonium benzoate, on pancreatic hormone secretion. Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E537-E544.
Smiles	CC[N+](CC)(CC(NC1=C(C)C=CC=C1C)=O)CC2=CC=CC=C2.O=C([O-])C3=CC=CC=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	THS-839
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Targets	Taste Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	446.58
Product Description	Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility[1] [2] [3][4].
Manufacturer - Research Area	Endocrinology; Inflammation/Immunology
Solubility	DMSO: 20 mg/mL (ultrasonic)\|H2O: 20 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein
Clinical information	No Development Reported

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HY-B1146-10mM-safety-datasheet.pdf