Cepharanthine

ArtNr	HY-N6972-50mg
Hersteller	MedChem Express
CAS-Nr.	481-49-2
Menge	50 mg
Quantity options	100 mg 10 mM/1 mL 50 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.87
Citations	[1]Hijikata A, et al. Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2. FEBS Open Bio. 2022;12(1):285-294\|[2]Shen LW, et.al. Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis. Acta Pharmacol Sin. 2022 Jan;43(1):177-193.\|[3]Ikeda R, et.al. Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. \|[4]Zhang X, et.al. In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes. Pharm Biol. 2020 Dec;58(1):247-252. \|[5]Hua P, et.al. Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):136-42. \|[6]Desgrouas C, et.al. In vitro antiplasmodial activity of cepharanthine. Malar J. 2014 Aug 22;13:327. \|[7]Murakami K, et.al. The prevention of lipopolysaccharide-induced pulmonary vascular injury by pretreatment with cepharanthine in rats. Am J Respir Crit Care Med. 2000 Jan;161(1):57-63. \|[8]Wei XY, et,al. Antinociceptive activities and mechanism of action of Cepharanthine. Biochem Biophys Res Commun. 2022 Jul 23;614:219-224.
Smiles	[H][C@]12N(C)CCC(C1=C3)=CC(OC)=C3OC4=C5C(OCO5)=CC6=C4[C@](N(C)CC6)([H])CC(C=C7)=CC=C7OC8=C(OC)C=CC(C2)=C8
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	481-49-2
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Autophagy; Cytochrome P450; Parasite; SARS-CoV
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	606.71
Product Description	Cepharanthine is a natural product that can be isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC50) and 90% inhibitory concentration (IC90) values of 1.90 and 4.46 μM[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model[2][3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects[4][5][6][7][8].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Isoform	CYP2; CYP3
Clinical information	Launched

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