Calphostin C (UCN 1028C, PKF115-584, Cal-C)

Blue Ice

790, 8

Dark red to brown solid

Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion.

Source:
Cladosporium cladosporioides sp.

Synonyms:
UCN 1028C, PKF115-584, Cal-C

Molecular Formula:
C44H38O14

Molecular Weight:
~790.8

Purity (HPLC):
≥95%

Appearance:
Dark red to brown solid

Solubility:
Ehanol, Methanol, DMSO or DMF. Poorly soluble in Water.

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute and aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.