Tyloxapol, USP

Biochemicals / Biochem-Molecular Biology

4°C

Yellow to brown viscous liquid

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent[citation needed] (containing mucus and pus) bronchopulmonary secretions administered by inhalation through a nebulizer or with a stream of oxygen. With intraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. This mechanism is used to induce experimental hyperlipidemia in animals. Tyloxapol is the main active ingredient of the medical device Tacholiquin®. Tacholiquin® is an expectorant designated for inhalation and instillation reaching the upper and lower airways.

Synonyms:
p-(1, 1, 3, 3-Tetramethylbutyl)Phenol Polymer with Ethylene Oxide and Formaldehyde; Ethylene Oxide Polymer with Formaldehyde and p-(1, 1, 3, 3-Tetramethylbutyl)phenol; Oxirane Polymer with Formaldehyde and 4-(1, 1, 3, 3-tetramethylbutyl)phenol; Ethylene oxide-formaldehyde-4-(1, 1, 3, 3-tetramethylbutyl)phenol copolymer; Ethylene oxide-formaldehyde-p-octylphenol Copolymer; NSC 90255; Superinone; Triton A 20; Triton WR 1339; Tyloxapol; p-Isooctylpolyoxyethylenephenol Formaldehyde Polymer

CAS No:
25301-02-4

Molecular Formula:
(C17H30O4)n

Appearance:
Viscous amber liquid, may exhibit slight turbidity

Identity (UV):
Conforms to structure. Exhibits maximum and minimum at the same wavelengths as RS

Identity (IR):
Conforms to structure

Cloud Point:
92-97°C

Free Phenol:
No cloudiness or precipitation immediately

Limit of Formaldehyde:
≤0.0075%

Ethylene Oxide:
≤0.001%

Limit of Anionic Detergents:
≤0.075% as sodium lauryl sulfate

Absence of cationic detergents:
No blue color in the organic solvent layer

Water (Karl Fisher):
≤1%

pH:
5-7

Residue On Ignition:
≤1%

Refractive Index (n25D):
1.495 - 1.501

Solubility:
Slowly but freely miscible with water.
Soluble in glacial Acetic acid, Toluene, and Chloroform.

Storage and Stability:
Store at 4ºC. Stable for 6 months after receipt.