Aminoglutethimide (BA-16038)

Description: Aminoglutethimide (also known as BA-16038, NSC-330915) is an an anticancer drug that acts as a nonsteroidal aromatase inhibitor with IC50 of 10 uM. Aminoglutethimide decreases the production of sex hormones such as estrogen in women or testosterone in men, and suppresses the growth of tumors that need sex hormones to grow. Aminoglutethimide blocks the production of steroids derived from cholesterol and is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer.

References: Eur J Med Chem. 2009 Oct; 44(10):4121-7; Cancer Res. 1982 Aug; 42(8 Suppl):3353s-3359s.

Related CAS#: 23734-88-5 (Aminoglutethimide phosphate); 55511-44-9 (D)-Aminoglutethimide; 57288-03-6 (S)-Aminoglutethimide; 57344-88-4 (R)-Aminoglutethimide tartrate; 62268-19-3 (S)-Aminoglutethimide tartrate