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Human PP2C alpha/PPM1A antibody

Human PP2C alpha/PPM1A antibody

ArtNr	NKM-APP0401-100ul
Hersteller	NKMAX
Menge	100 ul
Quantity options	100 ul 50 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ICC, ELISA
Clon	p6c7
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b Kappa
Konjugat/Tag	Unconjugated
Citations	Lin X, et al., (2006) Cell. 125(5): 915-928 Duan X, et al., (2006) J Biol Chem. 281(48):36526-32 Kim JS, et al. The interaction of hepatitis B virus X protein and protein phosphatase type 2 Calpha and its effect on IL-6. (Biochem Biophys Res Commun. 2006){https://pubmed.ncbi.nlm.nih.gov/17055456/} Kim YG, et al. Role of protein phosphatase magnesium-dependent 1A and anti-protein phosphatase magnesium-dependent 1A autoantibodies in ankylosing spondylitis. (Arthritis Rheumatol. 2014){https://pubmed.ncbi.nlm.nih.gov/24980965/} Pereira JM, et al. Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. (Cell Rep. 2018){https://pubmed.ncbi.nlm.nih.gov/29694890/}
NCBI	NP_066283
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Pyruvate dehydrogenase phosphatase catalytic subunit 1, Pyruvate dehydrogenase acetyl-transferring-phosphatase 1, Protein phosphatase Mg2+/Mn2+dependent 1A, Protein phosphatase 2C, Protein phosphatase 1A (formerly 2C) magnesium-dependent alpha isoform, Protein phosphatase 1A (formerly 2C), PPM2C, PPM1A, PP2CA, PP2C alpha, PDPC 1, PDP 1, PDP, MGC9201, FLJ42306, EC 3.1.3.43
Similar products	PPM1A, PDP1, PDP, PPM2C, Protein phosphatase 2C, Pyruvate dehydrogenase phosphatase catalytic subunit 1, PP2CA, FLJ42306, MGC9201, PP2Calpha, PP2C alpha, PP2C-alpha, PDP 1, PDPC 1, Pyruvate dehydrogenase acetyl-transferring-phosphatase 1, Protein phosphatase Mg2+/Mn2+dependent 1A, Protein phosphatase 1A (formerly 2C) magnesium-dependent alpha isoform, Protein phosphatase 1A (formerly 2C), PP2C A, EC 3.1.3.43, APP0401-10ug, APP0401-20ug, APP0401-50ug, APP0401-100ug, APP0401-250ug, APP0401-500ug, APP0401-1mg, APP0401-010, APP0401-020, APP0401-050, APP0401-100, APP0401-250, APP0401-500, APP0401-01M
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	ELISA, WB, ICC/IF
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Description	Protein phosphatase 2C (PP2Calpha) is a Mn2+ - or Mg 2+ -dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNk MAPk pathways and regulates cellular stress response in eukaryotes. The PPM (metal-dependent protein phosphatase) family of Ser/Thr protein phosphatases have recently been shown to down-regulate the stress response pathways in eukaryotes. Within the stress pathway, key signaling kinases, which are activated by protein phosphorylation, have been proposed as the in vivo substrates of PP2Calpha, the prototypical member of the PPM family.
Concentration	1mg/ml (determined by BCA assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Immunogen	Recombinant human PP2Calpha (1-382aa) purified from E. coli
Ab Usage	The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtainoptimal results.
Antigen Species	Human
Clonality	Monoclonal
Ab Purification Comment	By protein-G affinity chromatography
Gene Category	Signal Transduction
Manufacturer - Search Terms	Pyruvate dehydrogenase phosphatase catalytic subunit 1, Pyruvate dehydrogenase acetyl-transferring-phosphatase 1, Protein phosphatase Mg2+/Mn2+dependent 1A, Protein phosphatase 2C, Protein phosphatase 1A (formerly 2C) magnesium-dependent alpha isoform, Protein phosphatase 1A (formerly 2C), PPM2C, PPM1A, PP2C-alpha, PP2Calpha, PP2CA, PP2C A, PP2C alpha, PDPC 1, PDP1, PDP 1, PDP, MGC9201, FLJ42306, EC 3.1.3.43, APP0401-10ug, APP0401-20ug, APP0401-50ug, APP0401-100ug, APP0401-250ug, APP0401-500ug, APP0401-1mg, APP0401-010, APP0401-020, APP0401-050, APP0401-100, APP0401-250, APP0401-500, APP0401-01M
Manufacturer - Alternative Names	Pyruvate dehydrogenase phosphatase catalytic subunit 1, Pyruvate dehydrogenase acetyl-transferring-phosphatase 1, Protein phosphatase Mg2+/Mn2+dependent 1A, Protein phosphatase 2C, Protein phosphatase 1A (formerly 2C) magnesium-dependent alpha isoform, Protein phosphatase 1A (formerly 2C), PPM2C, PPM1A, PP2CA, PP2C alpha, PDPC 1, PDP 1, PDP, MGC9201, FLJ42306, EC 3.1.3.43

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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NKM-APP0401-100ul-datasheet.pdf

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Menge: 100 ul

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Lieferung vsl. bis 04.09.2025

Express-Lieferung: 10 Tage sparen

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