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Uridine 5′-diphosphoglucose

Uridine 5′-diphosphoglucose

ArtNr	HY-113044-10mg
Hersteller	MedChem Express
CAS-Nr.	133-89-1
Menge	10 mg
Quantity options	10 mg 1 mg 25 mg 5 mg
Kategorie	Reagents & Chemicals Biochemicals
Typ	Chemicals
Specific against	other
Citations	[1]DietrichKeppler, et al. Uridine-5′-diphosphoglucose. Methods of Enzymatic Analysis (Second English Edition). 1974;4:2225-2228.\|[2]Li K, et al. Upregulation of P2Y14 receptor in neutrophils promotes inflammation after myocardial ischemia/reperfusion injury[J]. Life Sci. 2023 Aug 1;326:121805. \|[3]Cortes P, Dumler F, Levin NW. De novo pyrimidine nucleotide biosynthesis in isolated rat glomerul[J]i. Kidney Int. 1986 Jul;30(1):27-34.\|[4]Das A, et al. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. Evid Based Complement Alternat Med. 23 Nov 2022\|J Am Chem Soc. 2020 Sep 16;142(37):16039-16050.\|Clin Immunol. 2024 Jun 29:110300.\|Research Square Preprint. 2021 Nov.\|SSRN. 2024 Jul 16.
Smiles	O[C@@H]1[C@H](O)[C@@H](COP(O)(OP(O)(O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)=O)=O)O[C@H]1N3C=CC(NC3=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	UDP-D-Glucose
Versandbedingung	Raumtemperatur
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Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Endogenous Metabolite; P2Y Receptor
Shipping Temperature	Room temperature
Molecular Weight	566.30
Product Description	Uridine 5’-diphosphoglucose (UDP-glucose), secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue[1][2][3][4].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	GPCR/G Protein; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite; Microbial Metabolite; P2Y14 Receptor
Clinical information	No Development Reported

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Menge: 10 mg

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