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Jatrorrhizine (hydroxide)

Jatrorrhizine (hydroxide)

ArtNr	HY-N0749A-20mg
Hersteller	MedChem Express
CAS-Nr.	483-43-2
Menge	20 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 20 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	98.07
Citations	[1]Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.\|[2]Xiaofei Jiang, et al. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Research Article Volume 2017\|[3]C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40.
Smiles	COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[OH-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	5-HT Receptor; Bacterial; Cholinesterase (ChE)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	355.38
Product Description	Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities[1]. Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE[2]. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters[3].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 3.33 mg/mL (ultrasonic)\|H2O: 2.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; GPCR/G Protein; Neuronal Signaling
Isoform	AChE
Clinical information	No Development Reported

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HY-N0749A-20mg-safety-datasheet.pdf