Capillarisin

IL Receptor|||NF-κB|||NOS|||VEGFR|||Bcl-2 Family|||MMP|||TLR|||MAPK|||ERK|||Prostaglandin Receptor|||DNA/RNA Synthesis|||STAT|||JNK|||COX|||TNF

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Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.