Recombinant Human Platelet Factor-4 (CXCL4V1) Variant-1

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

Escherichia Coli.

The protein was lyophilized without additives.

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Human CXCL4 although stable at 25C 1 week, should be stored desiccated below -18C.
Please prevent freeze-thaw cycles.