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Recombinant Human Platelet Factor-4 (CXCL4V1) Variant-1

Recombinant Human Platelet Factor-4 (CXCL4V1) Variant-1

Item no.	chm-243-5ug
Manufacturer	ProSpec
Amount	5ug
Category	Peptides & Proteins Recombinant Proteins
Type	Chemokines
Specific against	Human (Homo sapiens)
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Similar products	PF 4 Variant-1
Available
Synonyms	CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298
Introduction	Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
Description	CXCL4 Variant-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa. The CXCL4 Variant-1 is fused to 6xHis tag at N-Terminus and purified by standard chromatography techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered white lyophilized powder.
Formulation	The protein was lyophilized without additives.
Purity	Greater than 95.0% as determined by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Amino acid sequence	MHHHHHHEAE EDGDLQCLCV KTTSQVRPRH ITSLEVIKAG PHCPTAQLIA TLKNGRKICL DLQALLYKKI IKEHLES.
Storage	Human CXCL4 although stable at 25C 1 week, should be stored desiccated below -18C. Please prevent freeze-thaw cycles.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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chm-243-5ug-safety-datasheet.pdf