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Recombinant Clostridium botulinum Botulinum neurotoxin type B (botB),partial

Recombinant Clostridium botulinum Botulinum neurotoxin type B (botB),partial

ArtNr	CSB-EP533025DUJ1-20
Hersteller	Cusabio
Menge	20 ug
Quantity options	1 mg 10 ug 100 ug 20 ug 200 ug 50 ug 500 ug
Kategorie	Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Konjugat/Tag	Myc, HIS
Purity	Greater than 85% as determined by SDS-PAGE.
Sequence	PVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKA FKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVC EYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGE KLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKL ISNPGEVERKKGIFANLIIFGPGPVLNENETIDIG IQNHFASREGFGGIMQMKFCPEYVSVFNNVQENKG ASIFNRRGYFSDPALILMHELIHVLHGLYGIKVDD LPI
Protein Familie	Peptidase M27 family
Citations	Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids. Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Bontoxilysin-B
Lieferbar
Manufacturer - Conjugate / Tag	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Storage Conditions	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Molecular Weight	55.8 kDa
Buffer	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
General Research Areas	Microbiology
Relevance	Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-\|-Phe-77' bond of synaptobrevin-2.
Expression Region	2-441aa
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-\|-Phe-77' bond of synaptobrevin-2 (By similarity).
Subcellular Location	Botulinum neurotoxin B light chain: Secreted, Host cytoplasm, host cytosol, SUBCELLULAR LOCATION: Botulinum neurotoxin B heavy chain: Secreted, Host cell junction, host synapse, host presynaptic cell membrane
Gene Names	botB
Sequence Info	Partial
Organism	Clostridium botulinum (strain Okra / Type B1)

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CSB-EP533025DUJ1-20-datasheet.pdf

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Menge: 20 ug

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Lieferung vsl. bis 28.08.2025

Express-Lieferung: 3 Tage sparen

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