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Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified) Europäischer Partner

ArtNr FCM-H5283-50ug
Hersteller ACROBiosystems
Menge 50 ug
Quantity options 500 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Source Human FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (FCM-H5283) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # P55899-1 (FCGRT) & P61769-1 (B2M)).
Konjugat/Tag Unconjugated, Twin-Strep
Purity 90%
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / MABSol® Fc Receptors
Manufacturer - Conjugate / Tag
C-Twin-Strep | Native, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
33.8 kDa (FCGRT) & 11.7 kDa (B2M)
Manufacturer - Format
Powder
Description
Human FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (FCM-H5283) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # P55899-1 (FCGRT) & P61769-1 (B2M)).
Background
FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Molecule
FcRn (FCGRT & B2M)
Exp Region
Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M)
Characteristics
Human FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free, produced by co-expression of FCGRT and B2M, has a calculated MW of 33.8 kDa (FCGRT) and 11.7 kDa (B2M). Subunit FCGRT is fused with Strep II-tag at the C-terminus and subunit Beta-2 microglobulin (B2M) contains no tag. The reducing (R) protein migrates as 40-43 kDa (FCGRT) and 12 kDa (B2M) respectively due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH 7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state;
● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
lieferbar

Lieferung vsl. bis 28.08.2025 

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