Ganglioside GT1b, Trisodium Salt (GT1b 3Na, Trisialoganglioside GT1b 3Na)

Blue Ice

2126, 369

Supplied as a lyophilized powder.

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GT1b binds botulinum and tetanus neurotoxins and it prevents neurotoxicity of glutamate on neuronal cells.

Source:
Bovine brain

Synonyms:
Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal-NeuAc; Trisialoganglioside GT1b; IV3NeuAca2; II3NeuAca2-Gg4Cer

CAS No:
59247-13-1

Molecular Weight:
2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid)

Molecular Formula:
C95H162N5O47.3Na

Purity (TLC):
≥98%

Appearance:
White to off-white lyophilized powder

Solubility:
H2O (micellar aggregates) or chloroform:methanol (2:1)

Amino Acid Sequence:
IV3Neu5AcII3NeuAc2GgOse4Cer; a-Neu5Ac-(2-3)-beta-Gal-(1-3)-beta-GalNAc-(1-4)-[alpha-Neu5Ac-(2-8)-alpha-Neu5Ac-(2-3)-]beta-Gal-(1-4)-beta-Glc-(1-1)-Cer

Method of Determining Identity:
1H NMR and HPTLC.

Storage and Stability:
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.