Hersteller |
Sino Biological
|
Kategorie |
|
Typ |
Proteins |
Specific against |
Human |
Format |
Human Cell |
Menge |
100ug |
Host |
Human |
ArtNr |
11609-H01H2-100 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Molecule |
NRG1 |
Synonym |
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, Neuregulin 1, NRG1-IT2, SMDF |
Storage |
Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Protein Construction |
A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was fused with the Fc region of human IgG1 at the N-terminus. |
Expressed Host |
Human Cells |
Purity |
> 85 % as determined by SDS-PAGE |
Bio-Activity |
1. Measured by its binding ability in a functional ELISA. 2. Immobilized human Erbb3-his (cat: 10201-H08H) at 10 ug/mL (100 ul/well) can bind human NRG1 (aa 2-246)-Fc, The EC50 of human NRG1 (aa 2-246)-Fc is 0.16 ug/mL. 3. Immobilized Rhesus Erbb3-his (cat: 90043-H08H) at 10 ug/mL (100 ul/well) can bind human NRG1 (aa 2-246)-Fc, The EC50 of human NRG1 (aa 2-246)-Fc is 0.37 ug/mL. |
Endotoxin |
< 1.0 EU per ug of the protein as determined by the LAL method |
Predicted N Terminal |
Glu |
Molecule Mass |
The recombinant human NRG1(aa2-246?/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 505 amino acids and has a calculated molecular mass of 55.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 75 kDa due to glycosylation. |
Formulation |
Lyophilized from sterile PBS, pH 7.4 |
Accession |
Q02297-6 |
Amino acid sequence |
Ser2-Lys246 |
TAG |
N-human IgG1-Fc |
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