S-(5'-Adenosyl)-L-Methionine-d3 Disulfate Salt (Mixture of Diastereomers)

Blue Ice

597, 61

White to pale yellow solid

Labeled S-(5’-Adenosyl)-L-methionine. Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Synonyms:
5’-[[(3S)-3-Amino-3-carboxypropyl](methyl-d3)sulfonio]-5’-deoxyadenosine Disulfate; 5’-[(L-3-Amino-3-carboxypropyl)(methyl-d3)sulfonio]-5’-deoxyadenosine Disulfate; S-Adenosylmethionine-d3 Disulfate; Active Methionine-d3 Disulfate; Ademetionine-d3 Disulfate; L-S-Adenosylmethionin-d3 Disulfate; S-Adenosyl-L-methionine-d3 Disulfate

Molecular Formula:
C₁₅H₂₃D₃N₆O₁₃S₃

Molecular Weight:
597.61

Appearance:
White to pale yellow solid

Purity:
≥95% Chemical,
≥98% Isotopic

Melting Point:
>102°C (dec.)

Solubility:
Water (Slightly)

Method for Determining Identity:
Proton NMR spectroscopic analysis and Mass spectrometric analysis

TLC Conditions:
C18; Methanol: Water: Acetic Acid=5:5:0.02; Visualized with UV and KMnO4; Rf=0.40

Elemental Analysis:
Calculated: %C: 30.15, %H: 4.39, %N: 14.06

Normalized Intensity:
As Reported

Sulfate Content (Ion Chromatography):
~33%

Water Content (Elemental Analysis):
~3%

Storage and Stability:
Store at -20°C under an atmosphere of inert gas. Stable for 6 months after receipt. Caution: Hygroscopic.