Bisindolylmaleimide VIII acetate

Blue Ice

458, 6

Supplied as a red powder.

Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2).

Synonyms:
Ro 31-7549; BIM VIII

CAS Number:
138516-31-1

Molecular Weight:
458.60

Molecular Formula:
C24H22N4O2 . CH3COOH

Solubility:
DMSO, methanol or water. Slightly soluble in ethanol.

Appearance:
Supplied as a red powder.

Purity:
≥98% (NMR)

Storage and Stability:
Store at -20°C. Store solutions at -20°C in the dark. For maximum recovery of product, centrifuge the original vial prior to removing the cap.