Malformin C

RT

529, 7

Supplied as a white solid.

Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents.

Malformin C is a bicyclic pentapeptide containing L-leucine, D-isoleucine, L-valine, and two D-cysteines coupled with a disulfide-bond bridge. Malformins A1 and C, originally isolated from the culture broth of Aspergillus niger FKI-2342, were found to abrogate the bleomycin-induced G2 arrest in Jurkat cells with IC50 values of 480nM and 0.9nM, respectively. Malformins may be promising candidates as anti-cancer agents.

Source:
Synthetic. Originally isolated from Aspergillus niger FKI-2342.

Synonyms:
5-L-Leucine-Malformin A; BRN 4896114; (-)-cyclo[D-Cys(1)-D-Cys(1)-L-Val-D-Leu-L-Leu-]

CAS Number:
59926-78-2

Molecular Weight:
529.70

Molecular Formula:
C23H39N5O5S2

Solubility:
DMSO, methanol, ethanol or chloroform. Insoluble in water.

Appearance:
Supplied as a white solid.

Purity:
≥95% (HPLC)

Storage and Stability:
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.