Human 5-HT2AR Protein (S162K, M164W, S372N), Flag,His Tag (Detergent)

Protein

Dry ice

55.3 kDa

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

5-HT2AR

This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.3 kDa.

50 mM HEPES, 150 mM NaCl, Buffer B, pH7.5

glycerol