Pituitary Homeobox 2 (PITX2) Antibody

Pituitary Homeobox 2 (PITX2)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

PBS containing 0.09% sodium azide.

PITX2

Purified through a protein A column, followed by peptide affinity purification.

Predicted to react with Mouse, Rat, Chicken, Zebrafish and Xenopus PITX2.