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Homeobox Protein NANOG (NANOG) Antibody

Homeobox Protein NANOG (NANOG) Antibody

Manufacturer	Abbexa
Category	Antibodies Immunofluorescence Immunocytochemistry Primary Antibodies
Type	Antibody Primary
Specific against	Human
Isotype	IgG
Applications	IF, ICC
Amount	400 ul
Host	Rabbit
Item no.	abx028376-400
Conjugate/Tag	Unconjugated
eClass 6.1	32160702
eClass 9.0	32160702
Available
Antigen	Homeobox Protein NANOG (NANOG)
Description	NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cell proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.
Conjugation	Unconjugated
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9H9S0
UniProt Entry Name	NANOG_HUMAN
Buffer	PBS containing 0.09% sodium azide.
Dry Ice	No
Note	This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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