Comparison

DNA-Dependent Protein Kinase Catalytic Subunit (PRKDC) Antibody European Partner

Item no. abx001229-100
Manufacturer Abbexa
Amount 100 ul
Quantity options 100 ul 2 x 100 ul 20 ul 50 ul
Category
Type Antibody Primary
Format Liquid
Applications WB, IHC, ELISA
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Available
Manufacturer - Category
Primary Antibodies
Manufacturer - Targets
DNA-Dependent Protein Kinase Catalytic Subunit (PRKDC)
Manufacturer - Conjugate / Tag
Unconjugated
Storage Conditions
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight
Calculated MW: 469 kDa
Observed MW: 450 kDa
Description
PRKDC Antibody is a Rabbit Polyclonal antibody against PRKDC. PRKDC, also named as HYRC, HYRC1, DNPK1 and p460, belongs to the PI3/PI4-kinase family. PRKDC is a serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ), PRKDC is required for double-strand break (DSB) repair and V(D)J recombination. PRKDC must be bound to DNA to express its catalytic properties. It promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). It is required to protect and align broken ends of DNA. PRKDC may also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. It is found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. It also involved in modulation of transcription. It recognizes the substrate consensus sequence [ST]-Q. PRKDC phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. It phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC and RFA2. The antibody recognizes the C-term of PRKDC.
Dry Ice
No
Buffer
PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol.
Clonality
Polyclonal
Gene Symbol
PRKDC
Note
This product is for research use only.
Purification
Purified by affinity chromatography.
UniProt Entry Name
PRKDC_HUMAN
OMIM
600899

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close